About Citrus CBD

How Do You Get CBD from Citrus?

If you’re wondering how it’s possible to get CBD from citrus, you aren’t alone. When I first heard of citrus-derived CBD and spoke with the PureForm team, I was just as skeptical as you are. After getting to know George and learning more about citrus-derived CBD, however, I became convinced; PureForm is the real deal, and it has the potential to solve some of the biggest problems facing the CBD industry.

Is Citrus CBD Real CBD?

It turns out that extracting CBD from cannabis isn’t the only way to source this increasingly-popular cannabinoid. After years of research and extensive investment, CBD researchers have successfully developed a sustainable, cost-effective method for reassembling molecularly identical CBD from natural compounds found in citrus peels. This proprietary process, called Cyclic Terpene Assembly (CTA), sidesteps many of the legal complexities hindering the growth of the CBD industry and provides CBD users with non-hemp, non-cannabis, THC-free cannabidiol.

It’s understandable if that all sounds a little complicated. Let me break it down:

  • Terpenes are present in lots of different plants. Many citrus fruits contain terpenes.
  • These terpenes are chemically similar to cannabinoids. Cannabis contains tons of terpenes, and they help make some kinds of cannabis-derived CBD more effective.
  • It’s now possible to transform terpenes present in citrus plants into pure cannabidiol molecules. Using a proprietary process, the scientists behind PureForm have succeeded in creating a sustainable and cost-effective method for turning terpenes in citrus peels into CBD.
  • These citrus-derived CBD molecules are molecularly identical to cannabis-derived CBD molecules, which means that they have the same effects.

Legality of PureForm

Citrus-derived CBD is not a hemp, cannabis, or marijuana product. At present, the FDA has not decided on a regulatory structure for the CBD industry, and neither it nor any other agency worldwide has put restrictions on the CBD molecule itself. This molecule is not patented.

Whether in the USA or abroad, therefore, laws that pertain to cannabis, hemp, or marijuana do not apply to citrus-derived CBD. Also, like cannabis-derived CBD isolate, citrus-derived CBD does not contain any THC whatsoever, so it cannot be construed as a marijuana product. Since the citrus-derived CBD offered by PureForm does not contain any THC, it is not possible to fail a drug test for THC after using a PureForm product.

Citrus-derived CBD occupies a unique legal status within global cannabidiol law. Consumers can use PureForm products with confidence knowing that do not contain any THC and are in no way related to illegal drugs.

Definition of Terms

1. Cannabis/Hemp/Marijuana

While misleading marketing material for cannabis-derived CBD might have told you otherwise, cannabis, hemp, and marijuana are all the same plant. Some cannabis has simply been bred to be high in THC (marijuana), and some has been bred to be high in CBD (or not high in any cannabinoids at all).

2. Molecularly Identical/Bio-identical

These terms also mean the same thing. Under a microscope, citrus-derived CBD has the same molecular structure as CBD derived from cannabis.

Is Citrus CBD Molecularly Identical to Hemp CBD?

Yes, the citrus-derived CBD in PureForm is bio-identical to CBD in every way, shape, and form. Unlike full-spectrum CBD-rich hemp oil, the cannabidiol in PureForm does not contain omega fatty acids, terpenes, or other trace cannabinoids. In this way, it most closely resembles isolate CBD derived from cannabis plants, but it is not cannabis-derived.

Independent lab testing has confirmed that PureForm cannabidiol is molecularly identical to cannabis-derived cannabidiol. Essentially, citrus-derived CBD is the exact same thing as cannabis-derived CBD, but by acquiring this beneficial cannabinoid from a different source, citrus-derived CBD avoids the legal, quality-related, and purity-related concerns plaguing the CBD industry today.

Is Citrus CBD Synthetic?

Good question. The simple answer is, “No,” but it’s important to examine the complexities of this question to answer it thoroughly.

PureForm is made from the peels of citrus fruits, which means it’s derived from organic substances rather than synthetic chemicals. However, creating CBD from reconstructed terpenes does involve breaking down and reassembling molecular structures, so in one sense of the word, CTA “synthesizes” CBD from natural terpenes present in citrus peels.

Rest assured, however, that PureForm is all-natural and 100%-organic. It’s also worth pointing out once more that PureForm is molecularly identical to cannabis-derived CBD, which means that it’s the last thing from a synthetic analogue. Citrus CBD is a natural, pure, and scientific alternative to unreliable and legally-complicated hemp-derived CBD.

PureForm and the Environment

Hemp is usually grown and bred as a monoculture. Therefore, this practice degrades the soil even if organic farmers avoid using chemical pesticides and fertilizer. While hemp has dozens of uses, many CBD-rich cannabis cultivators do not use all the usable part of their plants. Additionally, hemp regulation is still in flux in the United States, and some hemp farmers do not have access to crop insurance, which leads to economic uncertainty.

In general, the U.S.-based cannabis-derived CBD industry is currently operating on the principle of, “Make hay when the sun shines.” There are quite a few ethical, high-quality cannabis-derived CBD manufacturers out there, but for every good producer, there are 10 more opportunists riding the “Green Rush” without putting enough thought into the quality or safety of their products. In the absence of effective regulatory oversight, the majority of cannabis-derived CBD manufacturers cut corners and overrepresent the safety and purity of their products.

PureForm, on the other hand, is molecularly restructured from citrus peels. It is 99.7-99.9% pure, and since PureForm was never grown, extracted, or stored as a plant oil, it cannot physically host any pesticides, fertilizers, or residual solvents.

Every year, citrus producers in Central and South America throw away millions of tons of citrus peels. PureForm puts these waste products to good use by turning natural citrus molecules into CBD. Hemp and cannabis, on the other hand, are “virgin” sources of CBD; they are grown expressly for the purpose of extracting CBD-rich hemp oil, and cannabis plants grown for CBD production may be discarded before their immense usefulness is fully exploited.

Benefits of Citrus-Derived CBD

Citrus-derived CBD is identical to cannabis-derived CBD, so it provides the same benefits. Science has discovered that the CBD molecule appears to provide a variety of different beneficial effects. First, let’s cover a couple of the mechanisms of action that scientists think help explain CBD’s observed benefits:

1. 5-HT1A Activation

The 5-HT1A neuroreceptor (serotonin 1A receptor) is the most abundant serotonin receptor in the brain. While many educated consumers are aware that serotonin has a big impact on mood, this neurotransmitter is also responsible for a variety of other critical biological functions. CBD’s reported antipsychotic, antidepressant, and anxiolytic effects appear to be related to this cannabinoid’s agonistic, or activating, effects at the 5-HT1A receptors.

2. TRPV1 Activation

CBD is observed to bind to the TRPV1 receptors, which modulate the perception of pain, seizures, and perhaps most importantly, inflammation. Some scientists believe that inflammation contributes to the pathophysiology (process of development) for every type of disease, and interactions with the TRPV1 receptor would also explain the potent antiepileptic effects that CBD has been observed to exert.

More Potential Benefits of CBD

  • Anti-inflammatory: May help with inflammatory conditions1;
  • Anti-acne: Appears to reduce inflammation, a perpetuator of acne and, potentially, this condition’s root cause2;
  • Anti-aging: Has been demonstrated to reduce oxidative stress, which causes aging;
  • Anxiolytic (anti-anxiety): Increased activation of the 5-HT1A receptors appears to reduce the symptoms of anxiety3;
  • Antipsychotic: May reduce the symptoms of schizophrenia4 and other psychotic conditions;
  • Antioxidant: Appears to reduce levels of free radicals, which cause oxidative stress;
  • Anticarcinogenic (cancer-preventing): Has been demonstrated to reduce oxidative stress, which causes DNA damage and can lead to cancer. Has also been shown to directly fight tumors5;
  • Anticonvulsant (anti-seizure): Has widely-demonstrated antiepileptic qualities6. Has been FDA-approved for epilepsy as the drug Epidiolex;
  • Neuroprotectant: Appears to exert antioxidant activity, which reduces neurological oxidative stress;
  • Sleep-inducing: Appears to modulate sleep patterns;
  • Anti-addiction (reduces drug-seeking behaviors): May be an effective treatment for alcohol, opioid, and cannabis addiction7;
  • Antiarthritic: Via reduction of oxidative stress and inflammation, appears to reduce symptoms of various arthritic conditions;
  • Autism-preventive: May reduce the symptoms of autism spectrum disorder (ASD)8;
  • Immune-boosting: Antioxidant and other activity may improve immune health;
  • Antidepressive: May increase activation of 5-HT1A receptors, which reduces the symptoms of depression;
  • …And more!

What About PureForm and the Entourage Effect?

Many well-informed CBD users are aware of the entourage effect, which is an observed

synergistic phenomenon that occurs when multiple cannabinoids and other cannabis constituents, such as terpenes, are used simultaneously. Citrus-derived CBD is similar to CBD isolate; aside from an exceedingly small amount of CBDA, the CBD in PureForm products does not contain any cannabinoids other than CBD.

Just as it’s possible to create CBD from citrus peels, however, it’s also possible to construct other cannabinoids from the natural compounds present in this unused waste product. The new PureForm Entourage Transdermal Patch contains a 5/1 ratio of CBD to cannabigerol (CBG), which is another non-psychoactive cannabinoid that has unique benefits above and beyond CBD.

With this product, PureForm is beginning to reconstruct the entourage effect using cannabinoids that aren’t derived from cannabis. In the future, it will be possible to choose whichever cannabinoids, terpenes, and other substances you want to include in your citrus-derived CBD topicals, capsules, and vape cartridges in whichever quantities you want. The more popular PureForm becomes, the closer this dream comes to reality.

How Much PureForm Can Your Body Absorb?

Citrus-derived, molecularly identical CBD may be more water-soluble than cannabis-derived CBD. Keep checking in as more research becomes available. What we know for sure, however, is that the body treats citrus-derived CBD similarly to cannabis-derived CBD. Therefore, it’s safe to say this much about absorption rates for this revolutionary non-hemp cannabinoid:

1. Oral Administration

Like cannabis-derived CBD, orally-administered CBD generally provides long-lasting, mild effects. However, some experts believe that more than 20% of the CBD you ingest internally is filtered out by the liver. While oral administration of CBD causes unique effects that many users find to be beneficial, this route of administration wastes a significant amount of the CBD you consume.

2. Pulmonary Administration

Pulmonary administration, or inhalation, of CBD provides better bioavailability than oral administration of this cannabinoid. However, the lungs still filter out a large percentage of the CBD you inhale. While pulmonary administration of CBD usually provides nearly immediate effects, the benefits of ingesting CBD via this method usually only last around half an hour.

3. Transdermal Administration

Research indicates that transdermal administration, also known as topical administration, is the most bioavailable method of CBD administration. Depending on the type of transdermal administration you choose, your body can use nearly 100% of CBD you apply to your skin. While the seven layers of your dermis are tricky to permeate, the skin’s filtration mechanisms hardly waste any of the CBD you apply.

Citrus-Derived CBD: The Bottom Line

It’s perfectly natural to be skeptical about citrus-derived CBD. In today’s CBD industry, cannabidiol users should be very cautious about the products they choose. With third-party lab testing confirming that the citrus-derived cannabidiol in PureForm is molecularly identical to cannabis-based CBD, there’s no denying that citrus-derived CBD is the real deal.

The CBD industry is in an imperfect state right now. Consumers are concerned that their access to CBD could dry up tomorrow. They’re even more concerned about the contaminants that might be present in their favorite CBD products, and even though the Agriculture Improvement Act of 2018 (2018 Farm Bill) made CBD legally separate from marijuana, cannabis-derived CBD remains in a legal gray area everywhere in the United States.

Citrus-derived CBD is not cannabis, it is not hemp, and it is not marijuana. It is, on the other hand, the pure cannabidiol molecule liberated from its relationship to the unstable, unreliable, and legally-volatile Cannabis sativa plant. While the CBD industry will always owe its origins to the cannabis plant, the advent of citrus-derived CBD proves that the cannabis industry does not have a monopoly on cannabidiol or any other cannabinoid. CBD can be reconstructed from natural citrus peel constituents and made into incredibly pure, cost-effective, and easy-to-use cannabidiol products.

While there are still many problems in the CBD industry, the products offered by PureForm go a long way toward solving them. It’s at the core of entrepreneurship to never be satisfied with achievements that have already been accomplished, and PureForm has taken the next steps toward providing cannabidiol users with safe, consistent, access to bioavailable and sustainable CBD.


  1. Cannabidiol as an Emergent Therapeutic Strategy for Lessening the Impact of Inflammation on Oxidative Stress
  2. The Role of Inflammation in the Pathology of Acne
  3. Antidepressant-like and anxiolytic-like effects of cannabidiol: a chemical compound of Cannabis sativa.
  4. Cannabidiol, a Cannabis sativa constituent, as an antipsychotic drug.
  5. Cannabidiol as potential anticancer drug
  6. Cannabinoids in the Treatment of Epilepsy: Hard Evidence at Last?
  7. Cannabidiol as an Intervention for Addictive Behaviors: A Systematic Review of the Evidence
  8. Oral Cannabidiol Use in Children With Autism Spectrum Disorder to Treat Related Symptoms and Co-morbidities

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